Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia
نویسندگان
چکیده
منابع مشابه
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT...
متن کاملhematopoietic stem cell transplantation in patients with severe acquired aplastic anemia: iranian experience
introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...
متن کاملUpfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant
BACKGROUND Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in SAA patients. METHODS We conducted a multicenter study b...
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We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of th...
متن کاملLate effects among pediatric patients followed for nearly 4 decades after transplantation for severe aplastic anemia.
Aplastic anemia (AA), a potentially fatal disease, may be cured with marrow transplantation. Survival in pediatric patients has been excellent early after transplantation, but only limited data are available regarding late effects. This study evaluates late effects among 152 patients followed 1-38 years (median, 21.8 years). Transplantation-preparative regimes were mostly cyclophosphamide with ...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2016
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2016.281